The M5 Motorway (Junctions 1 to 3) (60 Miles Per Hour Speed Limit) Regulations 2022 (Revocation) Regulations 2026

Published: Mon 7th Sept 26

Classified fifteen synthetic opioids and one synthetic cannabinoid as Class A controlled drugs effective 20 March 2024.


This Order amends Schedule 2 to the Misuse of Drugs Act 1971 to classify several synthetic opioids and a synthetic cannabinoid receptor agonist as Class A controlled drugs.

It places fifteen specific nitazene compounds and related substances, along with cumyl-peglaclone, under the strictest tier of drug control in the United Kingdom.

The measures apply to all individuals and entities within the UK, subjecting the possession, production, and supply of these substances to criminal penalties associated with Class A drugs.

Arguments For

  • The explanatory note states that the Order brings certain synthetic opioids and other substances under the control of the Misuse of Drugs Act 1971.

  • Proponents of the classification, as referenced in the accompanying impact assessments, argue that these synthetic opioids pose a significant risk to public health due to their high potency and association with fatal overdoses.

  • The document indicates the amendments follow consultation with the Advisory Council on the Misuse of Drugs (ACMD), as required by section 2(5) of the 1971 Act.

Arguments Against

  • Legal and policy commentators have noted that rapid classification of synthetic analogs can lead to a "cat-and-mouse" dynamic where manufacturers develop slightly altered chemical structures to evade specific listings.

  • Harm reduction advocates have expressed concerns that increasing criminal penalties for these substances may discourage individuals from seeking medical help during overdoses due to fear of prosecution.

  • Public health researchers have questioned whether classification alone is sufficient to address the underlying demand for high-potency synthetic opioids in the absence of expanded treatment services.

1. Citation and commencement

(1) This Order may be cited as the Misuse of Drugs Act 1971 (Amendment) Order 2024.

(2) This Order comes into force on 20th March 2024.

2. Amendments to the Misuse of Drugs Act 1971

(1) Schedule 2 to the Misuse of Drugs Act 1971 (which specifies the drugs which are subject to control under that Act) is amended as follows.

(2) In Part 1 (which specifies Class A drugs), in paragraph 1(a)—

(a) after “Diphenoxylate” insert—

“N-Desethyl etonitazene (etazene).

N-Desethyl isotonitazene.

N-Desethyl-protonitazene.”;

(b) after “Ethylmethylthiambutene” insert—

“Etonitazepyne (itoniepyne).

Etonitazene.”;

(c) after “Hydroxypethidine” insert—

“Isotonitazene.”;

(d) after “Metazocine” insert—

“Metonitazene.”;

(e) after “Nicodicodine” insert—

“Nitazene.”;

(f) after “Norpipanone” insert—

“N-Pyrrolidino-etonitazene (etonitazepyne).

N-Pyrrolidino-isotonitazene.”;

(g) after “Oxymorphone” insert—

“Para-nitrotodesnitazene.”;

(h) after “Proheptazine” insert—

“Protonitazene.”;

(i) after “Thebacon” insert—

“2-(4-Ethoxybenzyl)-5-nitro-1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzimidazole (etodesnitazepyne).

N-Desethyl-isotonitazene.

N-Desethyl-protonitazene.”;

(j) after “Trimeperidine” insert—

“5-Nitro-2-(4-propoxybenzyl)-1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzimidazole (protodesnitazepyne).”.

(3) In Part 2 (which specifies Class B drugs), in paragraph 1(ca), after “Cumyl-Pe-Pica” insert—

“Cumyl-Pegaclone.”.

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